What is COMPLERA®?

Pill shown is not actual size

COMPLERA combines
3 medicines in 1 pill

COMPLERA combines the medicines in TRUVADA® (emtricitabine and tenofovir disoproxil fumarate) + EDURANT® (rilpivirine) for a complete, 1-pill, once-a-day HIV-1 treatment.

COMPLERA is used to treat HIV-1 in people 12 years and older who are either:

Starting HIV-1 treatment and have never taken HIV-1 medicines before, and have no more than 100,000 copies/mL or virus in their blood, OR

Replacing their current HIV-1 medicines, have an undetectable viral load (less than 50 copies/mL), and whose healthcare provider determines that they meet certain other requirements.

COMPLERA does not cure HIV-1 infection or AIDS.

Talk to your HCP
if you have any
questions about COMPLERA.

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How to take COMPLERA

It’s important to take COMPLERA exactly as your healthcare provider tells you to.

  • 1 pill once a day

  • About the same
    time
    each day

  • With Food

Do not change your dose or stop taking COMPLERA without first talking with your healthcare provider. Stay under the care of your healthcare provider during treatment with COMPLERA and see your healthcare provider regularly.

Taking COMPLERA with food is important because it helps get the right amount of medicine in your body. Be sure the food contains at least 400 calories. A protein drink does not replace food.

Do not miss a dose of COMPLERA. If you miss a dose:

  • Within 12 hours of your regularly scheduled time, take your missed dose right away with food. Then, take your next dose as prescribed.
  • By more than 12 hours, wait and then take the next dose at the regularly scheduled time.

Do not run out of COMPLERA. Refill your prescription or talk to your healthcare provider before your COMPLERA is all gone.

COMPLERA is a complete treatment for HIV-1. Do not take it with other HIV-1 medicines unless recommended by your healthcare provider.

Taking COMPLERA with other medicines

COMPLERA may affect the way other medicines work, and other medicines may affect how COMPLERA works and may cause serious side effects.

Some medicines may also make the amount of COMPLERA in your body too low to help you control your HIV-1, and the virus may become resistant to COMPLERA.

DO NOT TAKE COMPLERA IF YOU ARE TAKING ANY MEDICINES THAT CONTAIN:

category Name
Certain antiseizure medicines
  • carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Tegretol-XR, Teril)
  • oxcarbazepine (Oxtellar XR, Trileptal)
  • phenobarbital (Luminal)
  • phenytoin (Dilantin, Dilantin-125, Phenytek)
Certain antituberculosis medicines
  • rifampin (Rifater, Rifamate, Rimactane, Rifadin)
  • rifapentine (Priftin)
Certain stomach acid blockers called proton
pump inhibitors (PPIs)
  • dexlansoprazole (Dexilant)
  • esomeprazole (Nexium, Vimovo)
  • lansoprazole (Prevacid, Prevpac)
  • omeprazole (Prilosec, Zegerid)
  • pantoprazole sodium (Protonix)
  • rabeprazole (Aciphex, Aciphex Sprinkle)

Other stomach medicines may be taken on a special schedule (see below).

Certain steroid medicines More than 1 dose of dexamethasone or dexamethasone sodium phosphate
Certain herbal supplements
  • St. John’s wort
Any other medicines to treat HIV-1 infection COMPLERA is a complete treatment for HIV-1. Do not take it with other HIV-1 medicines unless recommended by your healthcare provider.

Always tell your healthcare provider about all the medicines you are taking, including prescription medicines, over-the-counter medicines that you buy without a prescription, vitamins, and herbal supplements.

CERTAIN MEDICINES MAY AFFECT THE WAY COMPLERA WORKS

While taking COMPLERA, do not use certain stomach acid blockers called proton pump inhibitors (PPIs). However, other stomach medicines may be taken on a special schedule.

An antacid medicine that contains aluminum, magnesium hydroxide, or calcium carbonate (examples: Rolaids, TUMS) Take at least 2 hours before or at least 4 hours after you take COMPLERA
Other stomach acid blockers, including cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), or ranitidine HCl (Zantac) Take at least 12 hours before or at least 4 hours after you take COMPLERA. Ask your healthcare provider if your acid blocker is okay to take, as some acid blockers should never be taken with COMPLERA

Especially tell your healthcare provider if you take:

  • Antibiotic medicines, including rifabutin (Mycobutin). If you take rifabutin, talk to your healthcare provider about the right amount of rilpivirine (Edurant) you should take.

Important Safety Information

What is the most important information I should know about COMPLERA®?

COMPLERA can cause serious side effects:

  • Worsening of hepatitis B (HBV) infection. COMPLERA is not approved to treat HBV. If you have both HIV-1 and HBV and stop taking COMPLERA, your HBV may suddenly get worse. Do not stop taking COMPLERA without first talking to your healthcare provider, as they will need to monitor your health.

What is COMPLERA?

COMPLERA is a prescription medicine used to treat HIV-1 in people 12 years and older. It can be used in people who have never taken HIV-1 medicines before, and who have an amount of HIV-1 in their blood (“viral load”) that is no more than 100,000 copies/mL. It can also replace current HIV-1 medicines for some people who have an undetectable viral load (less than 50 copies/mL) and whose healthcare provider determines that they meet certain other requirements. COMPLERA combines 3 medicines into 1 pill taken once a day with food. COMPLERA is a complete HIV-1 treatment and should not be used with other HIV-1 medicines.

COMPLERA does not cure HIV-1 infection or AIDS. To control HIV-1 infection and decrease HIV-related illnesses, you must keep taking COMPLERA. Ask your healthcare provider if you have questions about how to reduce the risk of passing HIV-1 to others. Always practice safer sex and use condoms to lower the chance of sexual contact with body fluids. Never reuse or share needles or other items that have body fluids on them.

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Important Safety Information

What is the most important information I should know about COMPLERA®?

COMPLERA can cause serious side effects:

  • Worsening of hepatitis B (HBV) infection. COMPLERA is not approved to treat HBV. If you have both HIV-1 and HBV and stop taking COMPLERA, your HBV may suddenly get worse. Do not stop taking COMPLERA without first talking to your healthcare provider, as they will need to monitor your health.