How to take COMPLERA®

Whether you’re starting COMPLERA as your first HIV-1 treatment or using COMPLERA to replace your current treatment, it’s important to take it exactly as your healthcare provider tells you to.

Do not change your dose or stop taking COMPLERA without first talking with your healthcare provider. Stay under the care of your healthcare provider during treatment with COMPLERA and see your healthcare provider regularly.

Take 1 COMPLERA pill every day

Take COMPLERA at about the same time every day

Take COMPLERA with food

  • Taking COMPLERA with food is important to help get the right amount of medicine in your body
  • A protein drink does not replace food

The food you eat with COMPLERA should be at least 400 calories (more than a snack). Examples include:

  • Toast with peanut butter and fresh fruit
  • A roast beef sandwich
  • A grilled chicken Caesar salad

Please remember that a protein drink does not replace food.

Do not miss a dose of COMPLERA

If you miss a dose:

  • If you miss a dose of COMPLERA within 12 hours from the time you usually take it, take your dose of COMPLERA with food as soon as possible. Then, take your next dose of COMPLERA at the regularly scheduled time
  • If you miss a dose of COMPLERA by more than 12 hours of the time you usually take it, wait and then take the next dose of COMPLERA at the regularly scheduled time
  • Do not take more than your prescribed dose to make up for a missed dose

Do not run out of COMPLERA. Refill your prescription or talk to your healthcare provider before your COMPLERA is all gone.

Learn about taking COMPLERA with other medicines

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What is the most important information I should know about COMPLERA?

COMPLERA can cause serious side effects:

  • Build-up of an acid in your blood (lactic acidosis), which is a serious medical emergency. Symptoms of lactic acidosis include feeling very weak or tired, unusual (not normal) muscle pain, trouble breathing, stomach pain with nausea or vomiting, feeling cold especially in your arms and legs, feeling dizzy or lightheaded, and/or a fast or irregular heartbeat.
  • Serious liver problems. The liver may become large (hepatomegaly) and fatty (steatosis). Symptoms of liver problems include your skin or the white part of your eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); loss of appetite; nausea; and/or pain, aching, or tenderness on the right side of your stomach area.
  • You may be more likely to get lactic acidosis or serious liver problems if you are female, very overweight (obese), or have been taking COMPLERA or a similar medicine for a long time. In some cases, lactic acidosis and serious liver problems have led to death. Call your healthcare provider right away if you have any symptoms of these conditions.
  • Worsening of hepatitis B (HBV) infection. COMPLERA is not approved to treat HBV. If you have HBV and stop taking COMPLERA, your HBV may suddenly get worse. Do not stop taking COMPLERA without first talking to your healthcare provider, as they will need to monitor your health.


COMPLERA is a prescription medicine used to treat HIV-1 in people 12 years and older. It can be used in people who have never taken HIV-1 medicines before and who have an amount of HIV-1 in their blood (“viral load”) that is no more than 100,000 copies/mL. It can also replace current HIV-1 medicines for some people who have an undetectable viral load (less than 50 copies/mL) and whose healthcare provider determines that they meet certain other requirements. COMPLERA combines 3 medicines into 1 pill taken once a day with food. COMPLERA is a complete HIV-1 treatment and should not be used with other HIV-1 medicines.

COMPLERA does not cure HIV-1 infection or AIDS. To control HIV-1 infection and decrease HIV-related illnesses, you must keep taking COMPLERA. Ask your healthcare provider if you have questions about how to reduce the risk of passing HIV-1 to others. Always practice safer sex and use condoms to lower the chance of sexual contact with body fluids. Never reuse or share needles or other items that have body fluids on them.

Please click here to view additional Important Safety Information
for COMPLERA, including important warnings »

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